Wednesday, September 27, 2017

Translational Control in the Latency of Apicomplexan Parasites

2017 Sep 20. pii: S1471-4922(17)30211-8. doi: 10.1016/j.pt.2017.08.006. [Epub ahead of print]


Apicomplexan parasites Toxoplasma gondii and Plasmodium spp. use latent stages to persist in the host, facilitate transmission, and thwart treatment of infected patients. Therefore, it is important to understand the processes driving parasite differentiation to and from quiescent stages. Here, we discuss how a family of protein kinases that phosphorylate the eukaryotic initiation factor-2 (eIF2) function in translational control and drive differentiation. This translational control culminates in reprogramming of the transcriptome to facilitate parasite transition towards latency. We also discuss how eIF2 phosphorylation contributes to the maintenance of latency and provides a crucial role in the timing of reactivation of latent parasites towards proliferative stages.

KEYWORDS:

Plasmodium; Toxoplasma; eIF2; latency; translational control
PMID:
28942109
DOI:
10.1016/j.pt.2017.08.006

4 comments:

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Central Biohub said...

Toxoplasmosis is caused by Toxoplasma gondii, a parasite infection. It's one of the most prevalent parasites that infect humans and animals when they eat spoiled or badly cooked meat. Furthermore, the disease can be passed from mother to infant during pregnancy and through contact with contaminated cat feces. Toxoplasma infection affects more than 60% of the world's population and is a major public health concern.

https://centralbiohub.de/biospecimens/parasitology/toxoplamosis

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